The events of last season have left the Cross siblings in a crisis once again, they pull each other up from the trenches to continue on their quest to eradicate child trafficking and this time, they are taking it down from the top.
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Eric searches for Kenya, having to go to Benny Erica confronts Dr. Tiffany about the attempted murder on her twin brother Gemini must stop Cade from destroying the siblings for disrupting his trafficking operations in the Heights.
Erica and Eric are blamed for Robin's escape from prison as the three siblings learn the identity of Gemini Cross Nurse Brian's fears come to a head as a mysterious man named Cade enters town, terrorizing anyone in his path.
Dr. Tiffany and Nurse Brian cause turmoil in the Hospital among the staff Erica finds an attorney to help her sister Robin.
The events of last season have left the Cross siblings in a crisis once again, they pull each other up from the trenches to continue on their quest to eradicate child trafficking and this time, they are taking it down from the top.
Cintron and Erica's relationship reaches its breaking point Eric and Erica go undercover at the Mansion to find Layla while Robin has the same idea unbeknownst to anyone.
Eric and Tiffany are becoming closer than either of them expected Detective Ryan plans to infiltrate the auction in hopes of rescuing his daughter.
Layla plans her escape from the kidnapper Tanya and Officer Lopez team up to go after the clues that may bring them closer to finding Robin Cross.
Tiffany tries to convince Cintron to confess their past relationship to Erica Nurse Brian and Tiffany have immediate sparks between them Erica keeps her radar up when it comes to her old college roommate.
Nurse Brian struggles with his mental state as his dark side emerges DeAndre joins Robin to right her wrongs in the search for Layla Eric meets Keenya, a beautiful waitress that may have the missing pieces to the puzzle in his search.
Officer Lopez homes in on Erica regarding the disappearance of Dr. Lowes.
Eric tortures Chauncey, a street thug, for answers about the missing Keisha Jarvis Dr. Cintron admits his true feelings to Erica Detective Ryan sends Detective Candice home after she shows up at a murder scene intoxicated.
Eric helps Erica cover up the murder of her fiancé Eric and Erica vow to find the missing girls in their neighborhood by any means necessary Dr. Cintron pursues Erica and reveals he wants to mend their friendship.
As Dr. Erica Cross plans for a wedding, she is shocked to find out her ex is now working in the ER Detectives Candice and Ryan detain and question Erica's twin brother, Eric, about a murder.
Gege and Freaky Willie tie the knot and a wedding is celebrated a fight breaks out at Lollapalooza before KoldxWindy is set to perform betrayal and truth threaten Malika and Renee's relationship, forever finding themselves at a crossroads.
Under the murderous threats of the Mexican Cartel, Malika gets the help of Renee and Benji to pull off a deadly stain in record time against one of Chicago's most ruthless gangsters to pay her mother's debt Shelly Winter's world changes forever.
Renee finds out K-Town signed with Achieve Jamz and trashes the office losing KoldxWindy's record deal she gets closer with DeAndre's girlfriend, Tekila.
Malika struggles with suspecting Renee of killing Marlon. Renee takes out her frustrations and finds sexual comfort with DeAndre participating in a threesome. Gege goes through chemo treatment and Freaky Willie has a surprise for her.
Malika's behavior becomes more erratic, as she continues to spiral GeGe makes a decision about her cancer Shelly goes home to mixed messages Benji searches for Brenda.
Shelley's double life threatens those closest to her Detective Caine lays down the law on a vengeful father Malika plans a night out with Renee, but it backfires.
GeGe's business is in trouble Detective Caine's investigation hits close to home Temper contacts a rival Malika is surprised by a visitor.
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