When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can identification of a highly toxic metal in the victim's blood leads to his poisoner.
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Discovering that an assault suspect is left-handed is crucial to a police investigation dating back 16 years.
Janet Overton died suspiciously in 1988, and the investigation hit a dead end when the autopsy indicated no foul play was involved. A telephone tip and the sensitive nose of a forensic examiner indicated otherwise.
An investigation into the murder of Katie Poirier is stymied by the lack of a body. Finally, investigators use a single tooth found among some charred remains to identify her.
While investigating the murder of 9-year-old Jessica Knott, police use a garbage bag to connect a suspect.
The murders of an elderly couple leave police stumped until, two years later, they receive a major break.
When the mail-order bride of a former army sergeant goes missing, investigators look into the deaths of the man's previous two wives.
The 1996 investigation into 48-year-old Martha Hansen's murder is helped by a legal requirement that bars have video cameras installed on the premises.
After 6-year-old Michelle Lee Dorr went missing, her father confessed to murdering her. But investigators soon poked holes in his story, leaving the case unsolved for 14 years.
When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can identification of a highly toxic metal in the victim's blood leads to his poisoner.
The 1987 disappearance of Houston resident Tracy Jo Shine is recalled. The investigation went cold until 2000 when a "cold case squad" learned that the woman's ex-boyfriend Michael Neal had bragged about killing her.
A woman disappeared along a California highway in 1991. Three years later, the case was solved when a man's refrigerated truck was looked upon with suspicion.
While investigating an apparent overdose suicide, detectives recover incriminating files from a computer.
The disappearance of Philadelphia college athlete Aimee Willard is investigated after her car is found on the roadside. When her body is found, the police find unusual marks and DNA evidence that eventually lead to her killer.
When police discovered the body of Douglas Beamish's estranged wife, authorities linked 20 cat hairs found on her jacket to a cat owned by Beamish's parents. It was the first time animal DNA was used to solve a criminal case.
In 1991, a high school girl vanished after attending a party. The prime suspect had two alibi witnesses for the night she disappeared. A solid alibi can often overcome circumstantial evidence, but forensic evidence is another matter.
In 1988, the body of a young woman was discovered in an Ohio river. Most of the evidence had been washed away, but the victim's 6-year-old son unwittingly told investigators all they needed to know - without saying a word. The clue was in his genes.
When two boys are brutally attacked, investigators rely on evidence fished out of a nearby pond. It became the first case where diatom analysis was used to place a suspect at the scene of the crime.
When Chris Ochoa confessed to the 1988 rape and murder of Nancy DePriest, the case was closed. 8 years later, Achim Marino confessed to the same crime. Can DNA evidence identify the real perpetrator?
Exploring how an American hit single from 1966 -- "The Cheater" by Bob Kuban and the In-Men -- foreshadowed the demise of the group's lead singer, Walter Scott.
Lisa Manderach and her daughter Devon left their Pennsylvania home to go shopping but didn't return home.
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