A mystery is unraveled when an organization fighting to find a cure for vampirism enlists the help of one of the group. Old loyalties are put to the test with deadly results.
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In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces. In Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.
Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.
Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong. There, she learns to control her dark side and fights the B'ah, the second vampire Elder.
To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.
Vanessa is once again resurrected and must confront her family's legacy. Axel, Scarlett, and the others fend off Blak Tek's forces who hope to add Scarlett to their list of lab rats.
At a mountain stronghold, secrets of the Van Helsing family are unearthed and the true face of evil is exposed. A climactic battle between humans and vampires leaves humanity's fate in question.
While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe. Doc makes a medical discovery that could change everything.
Sam's and Mohamad's shared past comes back to haunt them in more ways than one. At a secluded campsite in the woods, friendships both old and new are put through a baptism by fire.
A mystery is unraveled when an organization fighting to find a cure for vampirism enlists the help of one of the group. Old loyalties are put to the test with deadly results.
Vanessa makes a horrific decision to save her daughter. Axel and a former ally struggle to survive in the wild.. A group of juvenile delinquents come face to face with a sadistic vampire.
Vanessa fights to get her daughter out of the citadel. Dmitri and Antanasia hatch a plot to stop Vanessa. Mohamad risks his life to save Vanessa and Dylan.
Vanessa and Mohamad search for Dylan as Dmitri's citadel crumbles around them. Flesh acquires an unexpected ally in one of the Resistance Fighters. Taka clashes with the Vampire Elite.
Now in Dmitri and Rebecca's clutches, Vanessa learns secrets from her past and finds herself at a crossroads - is she a vampire or a human?
While on the road to a vampire-controlled camp, Vanessa and Mohamad find themselves in a dangerous game of cat-and-mouse against Sam.
Vanessa and the group take shelter in Susan's family farm, finding both glimmers of hope and reasons for grief.
Still reeling from the dire events of 'The Farm', Vanessa and the group find refuge among a band of humans who have bargained with vampires for peace.
The group is trapped inside 'The Farm' - an underground lab for military experiments - and Vanessa discovers that Axel has been hiding a secret from her that concerns her past.
In the days leading up to 'The Rising', Vanessa is attacked and left for dead by an intruder.
Three years after 'The Rising' began, Vanessa - a mysterious dead woman - is resurrected in a world now ruled by vampires.
In the series finale, Vanessa assaults the Dark One in the Oval Office with daughters Violet and Jack, while Axel and Ivory protect a new government.
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