Trailer
Cast
Jackie Gonneau
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Jackie Flynn
School Janitor
Molly Shannon
Mrs. Boyd
Jonathan Adams
Officer Tom (voice)
Abe Farrelly
Bus Girl #2
Brandy Norwood
Leah (voice)
Bill Murray
Frank Detorre
John Melendez
Artie (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Laurence Fishburne
Thrax (voice)
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Danny Mann
Musician Cell (voice)
Steve Susskind
Mob Boss Germ (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Sherry Lynn
Trudy (voice)
Héctor Mercado
Additional Character Voices (voice)
Zak Penn
ER Doctor #3
Kid Rock
Kidney Rock (voice)
Rif Hutton
Charlie (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Keri Tombazian
Additional Character Voices (voice)
Robert Wisdom
Big Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
Chris Phillips
Firefighter Doug (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Nikki Tyler-Flynn
Nurse #2
Chris Rock
Osmosis Jones (voice)
Eddie Barth
Conductor (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Joel Silver
Police Chief (voice) (uncredited)
Chris Elliott
Bob
Elena Franklin
Shane Detorre
Donald Fullilove
Doughnut (voice)
Mickie McGowan
Brain Librarian (voice)
Sean Gildea
Dreamy Photographer
Zen Gesner
ER Doctor #1
Doug Stone
Police Officer Jamie (voice)
Danny Murphy
Zookeeper Superintendent
John-Eliot Jordan
Pea Soup Manager
Herschel Sparber
Bruiser (voice)
Paul Tuerpe
Additional Character Voices (voice)
Kevin J. Flynn
Docky's Clamshack Waiter
David Hyde Pierce
Drix (voice)
Carlos Alazraqui
Spanish Germ (voice)
Sally Brooks
Additional Character Voices (voice)