Trailer
Cast
Doug Stone
Police Officer Jamie (voice)
Héctor Mercado
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Danny Mann
Musician Cell (voice)
Keri Tombazian
Additional Character Voices (voice)
Jackie Flynn
School Janitor
Jonathan Adams
Officer Tom (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Mickie McGowan
Brain Librarian (voice)
Joel Silver
Police Chief (voice) (uncredited)
John-Eliot Jordan
Pea Soup Manager
Laurence Fishburne
Thrax (voice)
Bill Murray
Frank Detorre
Robert Wisdom
Big Germ (voice)
Elena Franklin
Shane Detorre
Carlos Alazraqui
Spanish Germ (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Rif Hutton
Charlie (voice)
Danny Murphy
Zookeeper Superintendent
Nikki Tyler-Flynn
Nurse #2
Donald Fullilove
Doughnut (voice)
Jackie Gonneau
Additional Character Voices (voice)
Paul Tuerpe
Additional Character Voices (voice)
Abe Farrelly
Bus Girl #2
Kevin J. Flynn
Docky's Clamshack Waiter
Sean Gildea
Dreamy Photographer
Zak Penn
ER Doctor #3
Chris Elliott
Bob
Janis Dardaris
Additional Character Voices (voice)
Antonio Fargas
Chill the Flu Shot (voice)
John Melendez
Artie (voice)
Chris Phillips
Firefighter Doug (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
David Hyde Pierce
Drix (voice)
Herschel Sparber
Bruiser (voice)
William Shatner
Mayor Phlegmming (voice)
Kid Rock
Kidney Rock (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Zen Gesner
ER Doctor #1
Chris Rock
Osmosis Jones (voice)
Ron Howard
Tom Colonic (voice)
Steve Susskind
Mob Boss Germ (voice)
Brandy Norwood
Leah (voice)
Molly Shannon
Mrs. Boyd
Sherry Lynn
Trudy (voice)