Trailer
Cast
Chris Rock
Osmosis Jones (voice)
Eddie Barth
Conductor (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Chris Phillips
Firefighter Doug (voice)
Herschel Sparber
Bruiser (voice)
David Hyde Pierce
Drix (voice)
John Melendez
Artie (voice)
Kid Rock
Kidney Rock (voice)
William Shatner
Mayor Phlegmming (voice)
Janis Dardaris
Additional Character Voices (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Joel Silver
Police Chief (voice) (uncredited)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Keri Tombazian
Additional Character Voices (voice)
Danny Murphy
Zookeeper Superintendent
Jackie Gonneau
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Sean Gildea
Dreamy Photographer
Brandy Norwood
Leah (voice)
Paul Tuerpe
Additional Character Voices (voice)
Carlos Alazraqui
Spanish Germ (voice)
Nikki Tyler-Flynn
Nurse #2
Bill Murray
Frank Detorre
Jonathan Adams
Officer Tom (voice)
Zen Gesner
ER Doctor #1
Elena Franklin
Shane Detorre
Laurence Fishburne
Thrax (voice)
Molly Shannon
Mrs. Boyd
Sally Brooks
Additional Character Voices (voice)
Héctor Mercado
Additional Character Voices (voice)
Kevin J. Flynn
Docky's Clamshack Waiter
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Rif Hutton
Charlie (voice)
Mickie McGowan
Brain Librarian (voice)
Steve Susskind
Mob Boss Germ (voice)
Jackie Flynn
School Janitor
Ron Howard
Tom Colonic (voice)
Chris Elliott
Bob
Abe Farrelly
Bus Girl #2
John-Eliot Jordan
Pea Soup Manager
Danny Mann
Musician Cell (voice)
Robert Wisdom
Big Germ (voice)
Zak Penn
ER Doctor #3
Donald Fullilove
Doughnut (voice)
Sherry Lynn
Trudy (voice)