Cast
John Goodman
The Dean (segment "Happy Birthday")
Sydney Tamiia Poitier
Hannah (segment "Happy Birthday")
David Hyde Pierce
Barney (segment "Happy Birthday")
Jenica Bergere
Sally (segment "Happy Birthday")
Ken Hudson Campbell
Security Guard (segment "Happy Birthday")
Taylor Negron
Policeman (segment "Happy Birthday")
Alan Rosenberg
Frank (segment "Reaching Normal")
Helen Mirren
Distinguished Woman (segment "Happy Birthday") (uncredited)
Caroline Rhea
Monica (segment "Happy Birthday")
Marissa Jaret Winokur
Dean's Secretary (segment "Happy Birthday")
Beverly D'Angelo
Bag Lady (segment "Happy Birthday")
Joel Grey
Dr. Mensley (segment "Reaching Normal")
Jean Kasem
Nurse (segment "Happy Birthday")
Anthony LaPaglia
Dr. Maas (segment "The Other Side")
Andie MacDowell
Lisa (segment "Reaching Normal")
Kathleen Wilhoite
Lucy (wraparound segments)
Paul Rudd
Kenneth (segment "Reaching Normal")
Travis Wester
Chute Boy (segment "Happy Birthday")
Bruce Davison
(segment "The Other Side")
Karen Sillas
Anna (segment "The Other Side")
Stephen Tobolowsky
Tom (wraparound segments)
Dondré Whitfield
Man in Elevator (segment "Happy Birthday")
Joey Lauren Adams
Sarah (segment "Reaching Normal")
Jolene Blalock
Charlie's Wife (wraparound segments)
Ellen DeGeneres
Operator (segment "Reaching Normal") (uncredited)
Christopher Lloyd
Attorney Bum (segment "Happy Birthday")
Kimiko Gelman
May Lee Ha (segment "Happy Birthday")
Scott Lowell
Charlie (wraparound segments)