Trailer
Cast
Bruce Willis
Spike (voice)
Cree Summer
Susie Carmichael (voice)
Nancy Cartwright
Chuckie Finster (voice)
Joe Alaskey
Lou Pickles (voice)
Tress MacNeille
Charlotte Pickles (voice)
Jack Riley
Stuart 'Stu' Pickles (voice)
Melanie Chartoff
Didi Pickles (voice)
Jodi Carlisle
Marianne Thornberry (voice)
Flea
Donnie Thornberry (voice)
E. G. Daily
Tommy Pickles (voice)
Tim Curry
Nigel Thornberry (voice)
Tara Strong
Dil Pickles (voice)
Cheryl Chase
Angelica Pickels (voice)
Danielle Harris
Debbie Thornberry (voice)
Tony Jay
Dr. Lipschitz (voice)
Ethan Phillips
Toa (voice)
Chrissie Hynde
Siri (voice)
Kath Soucie
Phil DeVille / Lil DeVille / Betty DeVille (voice)
Dionne Quan
Kimi Watanabe-Finster (voice)
Michael Bell
Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)
Phil Proctor
Howard DeVille (voice)
Julia Kato
Kira Watanabe-Finster (voice)
Lacey Chabert
Eliza Thornberry (voice)
Tom Kane
Darwin (voice)