Trailer
Cast
William Shatner
Mayor Phlegmming (voice)
Anne Lockhart
Female Red Blood Cell (voice)
John Melendez
Artie (voice)
Jackie Gonneau
Additional Character Voices (voice)
Héctor Mercado
Additional Character Voices (voice)
Sean Gildea
Dreamy Photographer
Molly Shannon
Mrs. Boyd
Paul Pape
Male Red Blood Cell #2 (voice)
Danny Murphy
Zookeeper Superintendent
Jackie Flynn
School Janitor
Abe Farrelly
Bus Girl #2
Eddie Barth
Conductor (voice)
Mickie McGowan
Brain Librarian (voice)
David Hyde Pierce
Drix (voice)
Sally Brooks
Additional Character Voices (voice)
Sherry Lynn
Trudy (voice)
Zak Penn
ER Doctor #3
Keri Tombazian
Additional Character Voices (voice)
Robert Wisdom
Big Germ (voice)
Donald Fullilove
Doughnut (voice)
Zen Gesner
ER Doctor #1
Steve Susskind
Mob Boss Germ (voice)
Rif Hutton
Charlie (voice)
Chris Phillips
Firefighter Doug (voice)
John-Eliot Jordan
Pea Soup Manager
Brandy Norwood
Leah (voice)
Bill Murray
Frank Detorre
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Chris Rock
Osmosis Jones (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Herschel Sparber
Bruiser (voice)
Nikki Tyler-Flynn
Nurse #2
Laurence Fishburne
Thrax (voice)
Joel Silver
Police Chief (voice) (uncredited)
Paul Tuerpe
Additional Character Voices (voice)
Kevin J. Flynn
Docky's Clamshack Waiter
Elena Franklin
Shane Detorre
Antonio Fargas
Chill the Flu Shot (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Danny Mann
Musician Cell (voice)
Carlos Alazraqui
Spanish Germ (voice)
Ron Howard
Tom Colonic (voice)
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Kid Rock
Kidney Rock (voice)
Janis Dardaris
Additional Character Voices (voice)