Trailer
Cast
John-Eliot Jordan
Pea Soup Manager
Mickie McGowan
Brain Librarian (voice)
Joel Silver
Police Chief (voice) (uncredited)
Paul Pape
Male Red Blood Cell #2 (voice)
Chris Phillips
Firefighter Doug (voice)
Jackie Flynn
School Janitor
Abe Farrelly
Bus Girl #2
David Hyde Pierce
Drix (voice)
William Shatner
Mayor Phlegmming (voice)
Herschel Sparber
Bruiser (voice)
Sean Gildea
Dreamy Photographer
Janis Dardaris
Additional Character Voices (voice)
Sherry Lynn
Trudy (voice)
Paul Tuerpe
Additional Character Voices (voice)
Kevin J. Flynn
Docky's Clamshack Waiter
Anne Lockhart
Female Red Blood Cell (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Keri Tombazian
Additional Character Voices (voice)
Carlos Alazraqui
Spanish Germ (voice)
Zak Penn
ER Doctor #3
Laurence Fishburne
Thrax (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Danny Murphy
Zookeeper Superintendent
Ron Howard
Tom Colonic (voice)
John Melendez
Artie (voice)
Steve Susskind
Mob Boss Germ (voice)
Jonathan Adams
Officer Tom (voice)
Jackie Gonneau
Additional Character Voices (voice)
Héctor Mercado
Additional Character Voices (voice)
Robert Wisdom
Big Germ (voice)
Brandy Norwood
Leah (voice)
Eddie Barth
Conductor (voice)
Rif Hutton
Charlie (voice)
Chris Rock
Osmosis Jones (voice)
Elena Franklin
Shane Detorre
Danny Mann
Musician Cell (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Kid Rock
Kidney Rock (voice)
Zen Gesner
ER Doctor #1
Bill Murray
Frank Detorre
Sally Brooks
Additional Character Voices (voice)
Nikki Tyler-Flynn
Nurse #2
Donald Fullilove
Doughnut (voice)
Richard Steven Horvitz
Additional Character Voices (voice)