In a desert infested with strange new vampires, Flesh and Axel chase a crazed Max who has Jennifer and Owen held hostage. When night falls, their chances of survival turn for the worse.
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With the amulet in hand, Vanessa and Lily Van Helsing escape from Elder Sam and return to the real world. As Denver falls to the Daywalkers, Hansen escorts Julius and Doc to Fort Collins.
Vanessa and Sam face off to find the Last Elder, with Scarlett, Axel and Mohamad caught in the crossfire. Julius fights the Sisterhood, while Doc unlocks the secrets in the Dark One's blood.
Scarlett is reunited with Axel but he is badly injured before they can find Vanessa. A mysterious man helps them find their way. Flesh and Jolene are fugitives on the run from Blaktek.
In his hometown, Axel fights both his tragic past and a vicious pack of Daywalkers. Sam can't find Mohamad, and takes his anger out on Chad and Mike.
Vanessa, trapped in an abandoned slaughterhouse, wrestles between the light and dark sides of her own self before she can move forward on her path to find the Final Elder.
Doc and Jolene clash with Denver authorities over the repellent. Flesh chooses to face his past. Axel struggles with leaving Scarlett behind. Ivory and the Sisterhood infiltrate Denver.
On a distant island, Vanessa and Scarlett battle the Third Elder which leads Vanessa to make a choice about her path forward, one that Scarlett does not agree with.
Sam moves closer to his destiny while Mohamad tries to free himself from imprisonment. Axel escorts San Francisco survivors to Denver. Ivory and Scab take control of the Daywalker horde.
Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
Vanessa is once again resurrected and must confront her family's legacy. Axel, Scarlett, and the others fend off Blak Tek's forces who hope to add Scarlett to their list of lab rats.
At a mountain stronghold, secrets of the Van Helsing family are unearthed and the true face of evil is exposed. A climactic battle between humans and vampires leaves humanity's fate in question.
While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe. Doc makes a medical discovery that could change everything.
Sam's and Mohamad's shared past comes back to haunt them in more ways than one. At a secluded campsite in the woods, friendships both old and new are put through a baptism by fire.
A mystery is unraveled when an organization fighting to find a cure for vampirism enlists the help of one of the group. Old loyalties are put to the test with deadly results.
A tense standoff between law enforcement and the survivors erupts into a bloodbath. In a bid to evade a vicious breed of vampire, Axel and Scarlett find themselves hunted like prey.
As the group struggles with the disappearance of one of its own, they accept sanctuary in a town run by its Sheriff and his troops. Meanwhile, Dmitri inches closer to achieving his darkest goal.
Vanessa faces off with Dmitri. Axel fights against becoming a full-fledged vampire. Sam tracks Mohamad, Flesh, and Lucky. Scab attempts to enlist a fierce group of vampires to join Dmitri.
Vanessa's past rushes back to confront her in an unexpected way. A secret that Doc has been protecting is revealed. In a bid to bolster his power, Dmitri sends Scab on an impossible mission.
While on the road to a vampire-controlled camp, Vanessa and Mohamad find themselves in a dangerous game of cat-and-mouse against Sam.
Vanessa and the group take shelter in Susan's family farm, finding both glimmers of hope and reasons for grief.
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