When plans for a weekend vacation hit a dead end, friends find themselves stranded in unfamiliar territory, pursued by a bloodthirsty predator. Holed up in an isolated cabin, the friends must fight to survive as the body count rises.
Forever damaged by their stint as the scientific subjects of hostile alien creatures, a trio of alien-abduction survivors -- Otis (Michael C. Williams), Duke (Brad William Henke) and Cody (Paul McCarthy-Boyington) -- troll the wooded site of their disappearance, heavily armed, in search of their attackers. After wounding a violent alien in the woods, the three drag its dying body to the home of reclusive fellow abductee Wyatt (Adam Kaufman), barricade themselves in and prepare for the worst.
When his brother dies, Larry Talbot (Lon Chaney) returns to Wales and reconciles with his father (Claude Rains). While there, he visits an antique shop and, hoping to impress Gwen (Evelyn Ankers), the attractive shopkeeper, buys a silver walking cane. That same night he kills a wolf with it, only to later learn that he actually killed a man (Bela Lugosi). A gypsy (Maria Ouspenskaya) explains that it was her son, a werewolf, that he killed, and that Larry is now one himself.
While in Tibet researching a mysterious flower that purportedly takes its strength from the moon, botanist Wilfred Glendon is bitten by a strange creature. Back in London, Glendon becomes absorbed in his research of the plant, and is annoyed by the appearance of fellow scientist Dr. Yogami, who reveals that the plant is the only known temporary antidote for werewolves. Glendon remains skeptical until the next full moon, when he undergoes a startling transformation.
After spending all the reward money from his first encounter with the giant man-eating worms called Graboids, Earl Bassett (Fred Ward) agrees to hunt more of the deadly creatures at a Mexican oil refinery for $50,000 each. Knowing that he cannot face the monsters alone, Earl recruits Burt Gummer (Michael Gross), another veteran of the incident in Nevada, to supply the firepower. There is only one problem: The Graboids have now evolved to attack above ground.
Short on cash, undergrad David Blake (Dirk Benedict) takes a job working as a lab assistant for snake expert Dr. Carl Stoner (Strother Martin). When Stoner begins giving David a series of antibiotics as a safeguard against snakebites, he at first thinks nothing of it. But gradually David begins to notices curious changes in his body, and his new girlfriend, Dr. Stoner's daughter, Kristina (Heather Menzies), notices them too. Could Dr. Stoner really be trying to turn his assistant into a snake?
Baron Wolf von Frankenstein (Basil Rathbone) is determined to prove the legitimacy of his father's scientific work, thus rescuing the family name from disgrace. With the help of Ygor (Bela Lugosi), a grave robber, Wolf successfully reanimates the monster (Boris Karloff) his father originally brought back from the dead. But when several villagers are killed mysteriously, Wolf must find the culprit in order to vindicate his creation, or face the possibility that he may be responsible.
Count Alucard (Lon Chaney) comes out of a lake in his coffin and makes a Southern belle (Louise Allbritton) his bride.
Grisly murders convince a turn-of-the-century Londoner that she is the latest in a long line of werewolves.
When young Fool (Brandon Adams) breaks into the home of his family's greedy and uncaring landlords, he discovers a disturbing scenario where incestuous adult siblings have mutilated a number of boys and kept them imprisoned under stairs in their large, creepy house. As Fool attempts to flee before the psychopaths can catch him, he meets their daughter, Alice (A.J. Langer), who has been spared any extreme discipline by her deranged parents. Can Fool and Alice escape before it's too late?
A lawyer (Robert Taylor) advises a blind man's rich widow (Barbara Stanwyck) tormented by nightmares.
A man (Lionel Atwill) uses mind over matter to replace his legs, then hunts the doctors who took them.
Pirate Captain Clegg (Peter Cushing), an English vicar by day, leads ghostly mounted smugglers by night.
An old archaeologist recalls the mummy Kharis, now at large in New England.
A professor turns into a Neanderthal killer after injecting himself with the blood of an ancient fish.
A mad scientist creates a monster when he transplants the brain of an executed murderer into the body of an ape.
A mad scientist (Lionel Atwill) makes an electric man (Lon Chaney Jr.) who glows and must wear a rubber suit.
A mad scientist (George Zucco) turns his assistant (David Bruce) into a zombie as part of a plan to steal his assistant's lover (Evelyn Ankers).
A fugitive doctor (Lionel Atwill) tries to raise the dead for South Sea Islanders.
A screwy professor's experiments with a gorgeous model attract the attentions of a gangster and a handsome millionaire.