In the early 1970s, Dr. Henry West creates an institute to find people with supernatural abilities. When Judith Winstead comes to the facility, she exhibits amazing abilities that the military wants to turn into a weapon.
When plans for a weekend vacation hit a dead end, friends find themselves stranded in unfamiliar territory, pursued by a bloodthirsty predator. Holed up in an isolated cabin, the friends must fight to survive as the body count rises.
Forever damaged by their stint as the scientific subjects of hostile alien creatures, a trio of alien-abduction survivors -- Otis (Michael C. Williams), Duke (Brad William Henke) and Cody (Paul McCarthy-Boyington) -- troll the wooded site of their disappearance, heavily armed, in search of their attackers. After wounding a violent alien in the woods, the three drag its dying body to the home of reclusive fellow abductee Wyatt (Adam Kaufman), barricade themselves in and prepare for the worst.
When his brother dies, Larry Talbot (Lon Chaney) returns to Wales and reconciles with his father (Claude Rains). While there, he visits an antique shop and, hoping to impress Gwen (Evelyn Ankers), the attractive shopkeeper, buys a silver walking cane. That same night he kills a wolf with it, only to later learn that he actually killed a man (Bela Lugosi). A gypsy (Maria Ouspenskaya) explains that it was her son, a werewolf, that he killed, and that Larry is now one himself.
Repairmen Val McKee (Kevin Bacon) and Earl Bassett (Fred Ward) are tired of their dull lives in the small desert town of Perfection, Nev. But just as the two try to skip town, they happen upon a series of mysterious deaths and a concerned seismologist (Finn Carter) studying unnatural readings below the ground. With the help of an eccentric couple (Reba McEntire, Michael Gross), the group fights for survival against giant, worm-like monsters hungry for human flesh.
In remote Antarctica, a group of American research scientists are disturbed at their base camp by a helicopter shooting at a sled dog. When they take in the dog, it brutally attacks both human beings and canines in the camp and they discover that the beast can assume the shape of its victims. A resourceful helicopter pilot (Kurt Russell) and the camp doctor (Richard Dysart) lead the camp crew in a desperate, gory battle against the vicious creature before it picks them all off, one by one.
When young Fool (Brandon Adams) breaks into the home of his family's greedy and uncaring landlords, he discovers a disturbing scenario where incestuous adult siblings have mutilated a number of boys and kept them imprisoned under stairs in their large, creepy house. As Fool attempts to flee before the psychopaths can catch him, he meets their daughter, Alice (A.J. Langer), who has been spared any extreme discipline by her deranged parents. Can Fool and Alice escape before it's too late?
A lawyer (Robert Taylor) advises a blind man's rich widow (Barbara Stanwyck) tormented by nightmares.
An old archaeologist (Dick Foran) recalls the mummy Kharis (Lon Chaney), now at large in New England.
A team of British archaeologists led by Sir Joseph Whemple (Arthur Byron) discover the mummified remains of the ancient Egyptian prince Imhotep (Boris Karloff), along with the legendary scroll of Thoth. When one of the archaeologists recites the scroll aloud, Imhotep returns to life, but escapes. Several years later, Imhotep has taken on the guise of a wealthy man, as he searches Egypt for his lost love, who he believes has been reincarnated as the lovely Helen Grosvenor (Zita Johann).
A mad scientist creates a monster when he transplants the brain of an executed murderer into the body of an ape.
A mad scientist (George Zucco) turns his assistant (David Bruce) into a zombie as part of a plan to steal his assistant's lover (Evelyn Ankers).
A fugitive doctor (Lionel Atwill) tries to raise the dead for South Sea Islanders.
A screwy professor's experiments with a gorgeous model attract the attentions of a gangster and a handsome millionaire.
A scientist (Bela Lugosi) seeks an antidote for a radium-poisoned colleague (Boris Karloff) with the touch of death.
While on a boating trip, Scott Carey (Grant Williams) is exposed to a radioactive cloud. Nothing seems amiss at first, but several months later Scott realizes that he's shrunk in height by several inches. He sees a doctor, who admits that he's baffled. As Scott continues to shrink, decreasing to three feet tall, he becomes bitter, and lashes out at his wife, Louise (Randy Stuart). He begins to fear a cure will never be found -- since even as he becomes a national sensation, he's still shrinking.
Shepherd Ygor (Bela Lugosi) rescues the monster (Lon Chaney) from a sulfur pit and brings him to Dr. Frankenstein's other son (Cedric Hardwicke).
Rebellious teen Amy (Elizabeth Berridge) defies her parents by going to a trashy carnival that has pulled into town. In tow are her boyfriend, Buzz (Cooper Huckabee), and their friends Liz (Largo Woodruff) and Richie (Miles Chapin). Thinking it would be fun to spend the night in the campy "Funhouse" horror ride, the teens witness a murder by a deformed worker wearing a mask. Locked in, Amy and her friends must evade the murderous carnival workers and escape before it leaves town the next day.
When famous radio hypnotist Alex Gregor (Lon Chaney Jr.) accidentally causes the death of an audience member during a broadcast, his guilt leads him to break off his engagement to Maura Daniel (Evelyn Ankers) and take a job at a wax museum. Jealousy over the attention paid to his new co-worker causes mentally unbalanced sculptor Rudi Poldan (Martin Kosleck) to lash out at museum owner Valerie Monet (Tala Birell) and her niece Nina (Elena Verdugo) in a horrifying fashion.
Desert scientists (John Agar, Mara Corday, Leo G. Carroll) try to stop a fortified spider the size of a building.