Jessica tries to clear Dr. Hazlitt after he is threatened with a possible malpractice suit when the owner of Cabot Cove's computer company dies.
Jessica suspects a setup when her Irish colleague is charged with murdering his longtime nemesis, who is killed shortly after moving to the United States.
After her husband (Kevin McCarthy) is murdered, an actress neighbor (Kate Mulgrew) involves Jessica in the investigation into the crime.
While in London, Jessica becomes involved in a murder cover-up by the British Intelligence Agency when she happens upon a disappearing corpse.
While visiting an old friend (Dina Merrill) who runs a Monte Carlo hotel, Jessica investigates the murder of a ruthless businessman with numerous enemies.
The would-be producer (Ron Leibman) of the movie adaptation of Jessica's latest book dies, leaving Jessica to identify possible suspects.
Cabot Cove suspects a woman (Mary Crosby) playing a witch in a community play is the real thing guest Robert Vaughn.
Jessica is convinced that a ballerina who died during her premiere performance in a new ballet was actually murdered.
Sheriff Metzger assumes his younger brother, the black sheep of the family, is guilty of murder, as charged.
A friend (Bradford Dillman) is suspected of killing the author (Jessica Walter) who was writing an unauthorized biography of his wife.
A policeman-turned-professor challenges Jessica to solve a series of campus muggings that soon escalates to murder.
Jessica takes a teaching position in New York, gets an apartment and finds its previous tenant murdered.
A writer is murdered after sending Jessica a manuscript exposing a kidnapping scam, and Jessica's friend, private investigator Harry McGraw (Jerry Orbach) is caught near the body.
Jessica comes to the aid of a small-town diner's owner (Dee Wallace Stone), who becomes an outcast when she is blamed for three arsenic poisoning deaths.
While traveling with her publisher's assistant in Amish country, Jessica's involvement in a traffic mishap leads her to a murder.
Jessica is pulled into a murder investigation by a woman (Vera Miles) who claims Jessica's husband fathered her son.
A member of Jessica's fan club mysteriously dies while impersonating her to investigate cheating at a dog show.
Sheriff Metzger (Ron Masak) defies political pressure and arrests an ambassador's son for murder, then is accused of the crime.
Dennis Stanton (Keith Michell) investigates when he is accused of murdering his girlfriend's estranged husband.
Jessica and Seth inadvertently get entangled in a crime family's power struggle after a sniper attack in Boston wounds a mob boss.