Jessica investigates the murder of one of Cabot Cove's most illustrious citizens, a world-famous artist (Foster Brooks).
Jessica's trainer friend, Harry McGraw (Jerry Orbach), faces charges of killing a shady fight promoter.
Jessica probes the murder by poison of an ex-colleague's understudy (Ann Turkel), after the leading lady (Eleanor Parker) is unable to go on at a small-town theater.
Jessica reluctantly agrees to a television interview for an old friend but is surprised when a different reporter arrives to conduct the taping a boat explosion leads everyone to believe the journalist (Chad Everett) has been killed.
Feeling professionally threatened, detective Magnum (Tom Selleck) resists Jessica's efforts to prove he was framed.
Jessica joins old friend Haskell Drake (Harry Guardino) to investigate a corrupt publisher's unexpected death.
An old beau of Jessica's (Leslie Nielsen) incites murder and greed when he seeks sunken treasure in Cabot Cove.
With a corned beef sandwich as the only clue, Jessica works to clear her niece (Genie Francis) of an ad executive's murder.
A mysterious man involves Jessica in the defection of two European musicians and the murder of a British intelligence agent.
A police retiree tries to solve a 10-year-old murder case reopened by a mistaken-identity shooting.
The ruthless new owner (Bert Convy) of a formerly classy periodical is murdered, and Jessica takes on the case.
A corpse, returned to Cabot Cove for burial, turns out to be misidentified.
Jessica and Boston private detective Harry McGraw (Jerry Orbach) seek a murderer and the thief of a dead sex-symbol's diary.
Murder plays a part in the death of a wealthy woman who leaves her fortune to an evangelist instead of her family.
Jessica and a colleague (Craig Stevens) encounter a mob ready to lynch a man suspected of murdering a bully.
Tainted strawberry preserves make several patrons ill and seem to be the cause of one woman's death at a popular inn.
Jury foreman Jessica doubts a married man's (Tony Bill) self-defense claim in the death of his lover's husband.
Jessica suspects a murderous cover-up in a cosmetics firm run by volatile siblings (Jayne Meadows, Robert Culp).
Jessica heads to London in answer to a foreboding message from her cousin (Angela Lansbury in a dual role).
Jessica is drawn into the investigation when an obnoxious man is murdered on the weekend she visits a college campus.