Jessica becomes involved in an internal police investigation when a colleague is left for dead in an accident in which a rookie policeman is killed.
Jessica is enjoying a Caribbean cruise on a ship where her old friend (Keith Michell) is chief of security when a woman is found dead in the ship's cargo net.
While attending a writers' conference in Florida, Jessica stumbles onto old photos that may be linked to the JFK assassination.
One of Jessica's students is framed for murder when someone uses information from her creative writing class to kill a local crime boss.
Seth's friend (Peter Donat), an actor coming out of retirement to launch a play is implicated in the murder of his ex-manager (Bradford Dillman).
Jessica uses her knowledge of music to investigate the murder of the owner of the record company that is producing one of her mysteries on tape.
The future son-in-law (Sean O'Bryan) of a prominent Cabot Cove family is suspected in the shooting of a hardware store employee.
Jessica investigates the mysterious disappearance of her editor's millionaire father along with $150 million from his corporate account.
Michael Hagarty (Len Cariou) is suspected of murdering his future son-in-law, thought to be involved in an illegal banking scheme.
Jessica is in the process of designing a murder-mystery board game for a toy company when an executive (Barbara Babcock) is murdered.
Seth's old Army pal (Gerald S. O'Loughlin) is accused of murdering his new employer (Cliff DeYoung), a yacht dealer.
Jessica consoles a playwright (Darren McGavin) after his wife's suicide, then realizes that he was the intended victim of a family member's murder.
While in Mexico City, Jessica researches two crimes when a mask stolen from the National Museum is found on the face of a murder victim.
Jessica tries to clear Dr. Hazlitt after he is threatened with a possible malpractice suit when the owner of Cabot Cove's computer company dies.
Jessica suspects a setup when her Irish colleague is charged with murdering his longtime nemesis, who is killed shortly after moving to the United States.
After her husband (Kevin McCarthy) is murdered, an actress neighbor (Kate Mulgrew) involves Jessica in the investigation into the crime.
While in London, Jessica becomes involved in a murder cover-up by the British Intelligence Agency when she happens upon a disappearing corpse.
After Jessica speaks at an exclusive men's club, they ask her to investigate when one of their members is murdered and they are all suspects.
Jessica tries to disprove charges against her friend's boyfriend, suspected of murdering a Las Vegas casino manager.
Jessica attempts to prove a battered wife innocent of killing her husband after failing to convince the woman to defend herself.