A bullet-riddled car, a missing driver, and no witnesses, an ambush or a random attack the clue was something so tiny, it was measured in millionths of a meter.
In 2006, Darlene VanderGiesen received threatening emails and then disappeared. Tracking the source of the emails led police to the home of Daphne Wright, where they believe a murder was committed.
In 2006, Nevada politician Kathy Augustine died mysteriously during a hard-fought re-election campaign and the medical examiner could neither isolate the cause of death.
Doctors don't know why a scientist is gravely ill. When tests reveal the cause, it's too late to save him.
In 2007, the Florida mobile home of Effie and Michael Ratley catches fire. Michael heroically rescues his wife and infant son. A month later, his wife is found beaten to death in a bedroom of his parents' home.
A brutal murder, lots of suspects and conflicting evidence but the forensics were clear on one thing: The killer knew his victim. And that alone gave investigators a head start.
A young, attractive hairdresser was sexually assaulted and murdered in her own beauty salon. The evidence at the crime scene didn't match any of the suspects and the case went cold for ten years.
When court clerk Peter Porco doesn't report to his work in November 2004, a courts officer is ordered to the Porcos' family home in Bethlehem, NY.
James Kenneth Elmen Jr. abducted Julie Estes, then 21, from the Southside convenience store where she worked in 1985.
A young woman is found dead in her apartment. With little evidence at the scene, the case turns cold.
Responding to a 2008 garage fire, Illinois emergency response discovered a man crushed beneath a truck.
A woman was found dead on the bedroom floor of her apartment. The crime scene yielded little of value and investigators wondered if they would find enough evidence to make a case.
A lifelong resident of the tiny town of Lefroy, Tasmania was murdered outside his own home. Robbery appeared to be the motive, but with no suspects, the investigation came to a halt.
Digital enhancement of security camera video shows that what appears to be a casual encounter is actually a forced abduction, leading to murder.
A murder trail turned cold, until police got a call from a woman whose husband, Gerald Powers, had a criminal past and a fondness for Chevy Berettas.
A millionaire and his family were executed in their own home. For three years, the murders went unsolved. Finally, a box of ammunition and some fluorescent fibers revealed the ultimate betrayal.
When a hit-and-run boating accident caused a death, police must search for one boat among 1200 others.
A wealthy man and his wife were attacked by three masked men outside their luxurious Louisiana home. He was shot dead and she was forced to open their hidden safe.
Police are able to create a composite sketch of a man burnt beyond recognition. But tracking the killer is more challenging.
The crime scene was especially violent: A couple had been shot to death. Was their teenage daughter complicit?