In 1997, Kelly Eckart's car was found, with her belongings still in it, after she worked a late shift in Franklin, Indiana. Days later, her body was found in an isolated ravine.
A man was killed in a car crash, but the evidence led investigators to believe it was not an accident.
When a woman went missing, friends and family were determined to find her. Their worst fears were confirmed weeks later when her body was discovered.
In 2003, Tiffany Rowell and three of her friends were brutally murdered in affluent Clear Lake, Texas.
In 1991, Dorothy Donovan was murdered in her Dover, Delaware home and police are skeptical when her son Charles Holden stated that she was murdered by a hitchhiker he had picked up.
In 2000, Judy Southern arrived home from work and was shot by a gunman waiting within. Her husband Allen arrived shortly afterwards, called 911 to report his wife had been shot.
In 2006, Texas real estate agent Sarah Anne Walker was found brutally murdered in a model home.
It was one of the most unusual cases in forensic history. Investigators had to find a way to solve a murder case with evidence which consisted of a squashed tomato found at the crime scene.
In 2006, Darlene VanderGiesen received threatening emails and then disappeared. Tracking the source of the emails led police to the home of Daphne Wright, where they believe a murder was committed.
A brutal murder, lots of suspects and conflicting evidence but the forensics were clear on one thing: The killer knew his victim. And that alone gave investigators a head start.
A six-year-old girl ran and hid when she saw her grandmother being beaten to death, but the man followed, beat and assaulted her. She said the assailant was her uncle, who was convicted.
When a little girl got sick and died, investigators were stumped. Was it an accident, an unexplained illness or murder?
In 2008, the body of Colorado real estate developer Alan Helmick was found by his wife, Miriam, who then became the prime suspect.
The crime scene was especially violent: A couple had been shot to death. Was their teenage daughter complicit?
James Kenneth Elmen Jr. abducted Julie Estes, then 21, from the Southside convenience store where she worked in 1985.
In 2004, Mary Ann Clibbery was found brutally murdered in her Illinois business and investigators had to determine if this was a robbery gone wrong or a calculated murder.
A surgeon is stabbed to death, and the most likely suspect is seen in a restaurant at the time of the murder.
The victim has been stabbed more than thirty times, and the crime scene is awash with her blood. Near her head, police discover a distinctive button with strands of thread still attached.
Tracey Frame, 35, was convicted of killing David Nixon in April 2002 after he planned to end their relationship.
Kathy Lorick was murdered on a Concord, California jogging trail while talking to her husband on her phone.