When a dedicated, well-respected teacher disappeared, police had to determine if she'd gone on vacation without telling anyone, or if she was the victim of foul play.
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A college senior was found raped and murdered near an unpaved footpath used by students to walk from one side of campus to the other.
In 2000, Judy Southern arrived home from work and was shot by a gunman waiting within. Her husband Allen arrived shortly afterwards, called 911 to report his wife had been shot.
Fifteen years later, DNA technology leads to justice for a murdered woman and her savagely beaten 4-year-old daughter.
In 2006, Nevada politician Kathy Augustine died mysteriously during a hard-fought re-election campaign and the medical examiner could neither isolate the cause of death.
In 1969, phone operator Diane Maxwell is murdered. Her brother promised he'd find out who was responsible.
In 1996, Virginia Beach police arrive at the Makdessi apartment to find Elise Makdessi and her lover dead.
Rachael Mullenix, 19, was convicted of stabbing her mother and then packing her bloodied corpse in a box.
A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.
On Halloween night 2004, Adriane Insogna and Leslie Mazzara were brutally murdered in their Napa home.
When a hit-and-run accident claimed the life of a high school athlete, everyone in town mourned his passing. Finding the killer was a long shot at best.
Even though their daughter had run away before, she'd always come back. Her parents were sure this time would be no different, but they were wrong.
Doctors don't know why a scientist is gravely ill. When tests reveal the cause, it's too late to save him.
A family break turns into a nightmare when the wife is found face-down in a lake with no idea whether it was murder, an accident or suicide, police turn to a new forensic technique.
A murder trail turned cold, until police got a call from a woman whose husband, Gerald Powers, had a criminal past and a fondness for Chevy Berettas.
Paul Gruber's daughter suspected something was wrong when she received birthday cards addressed from her father, but written in a stranger's handwriting.
A man's wife took her own life and his college sweetheart killed herself the same way. Was it coincidence?
Detectives search for the bombers of two churches in Illinois, hoping that the materials used in the remnants of the handmade bombs will offer the clues to catch the culprits.
In 1991, Dorothy Donovan was murdered in her Dover, Delaware home and police are skeptical when her son Charles Holden stated that she was murdered by a hitchhiker he had picked up.
In 2003, Tiffany Rowell and three of her friends were brutally murdered in affluent Clear Lake, Texas.
In 2005, David Castor suffered a slow, agonizing death over a period of days. His wife maintained it was suicide, even though it was done with antifreeze.
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