In 1991, Dorothy Donovan was murdered in her Dover, Delaware home and police are skeptical when her son Charles Holden stated that she was murdered by a hitchhiker he had picked up.
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In 1994, Rhoda Nathan was found murdered in a Cincinnati hotel room. When hotel employee Elwood Jones visited the emergency room for an infected hand, which he said was cut on a dumpster, the doctor recognized the injury as something else.
Lisa Manderach and her daughter Devon left their Pennsylvania home to go shopping but didn't return home.
Sometime during a neighborhood Christmas party, five-year-old Melissa Brannen disappeared. Investigators turned to forensic science to help them see what the witnesses missed.
A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.
When a decomposed body is found stuffed in a barrel, it's easy to presume murder. One of the few clues was an address book found along with the body.
An 11-year-old Boy Scout comes down with a fever and diarrhea after eating an undercooked burger. When his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.
While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.
A child was killed in a hit-and-run. The prosecutor has an accident reconstruction expert come to trial.
For more than a year, hateful letters were sent to a school teacher in Pennsylvania. DNA analysis would eventually help seal the perpetrator's fate.
When the wife of a well-known dentist is found dead, police struggle to identify a suspect. Some fibers and a study of the weather patterns on the night of the murder break the case open.
In 1999, nine-year-old Valiree Jackson vanished on her way to school near Spokane, WA. Her father Brad Jackson reported the disappearance and the entire community started searching for her abductor.
Robert Sims returned home after working the night shift and found his wife, Paula, unconscious on the kitchen floor. Their two-year-old son, Randy, was asleep in an upstairs bedroom, but their six-week-old daughter, Heather, was missing.
Police investigate a missing college girl and discover her double life: attending school by day and working as a call-girl by night. Her body is found and investigators find her killer.
Eileen and Derrick Severs disappeared from their home in the small village of Hambleton in Great Britain.
When DNA proves that a man who practically admits to a brutal attack is innocent, police wonder why he is willing to take the blame.
In 2003, St. Cloud teenager Jason MacLennan returned home after a night out with friends and discovered his father Ken's body lying in a pool of blood.
Detectives search for the bombers of two churches in Illinois, hoping that the materials used in the remnants of the handmade bombs will offer the clues to catch the culprits.
A Michigan State University grad student disappeared and was presumed dead. With the help of a professor of geological sciences, police hoped to get the "dirt" on her killer.
A woman was brutally murdered in her home and the only witnesses to the crime were the family dogs. An expert in canine behavior was convinced the killer knew both the victim and the animals.
In 1999, Susan Fassett was gunned down as she left her church choir practice in Poughkeepsie, NY. After clearing her husband, police turned their attention to Fred Andros, with whom Susan had an affair.
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