When a dedicated, well-respected teacher disappeared, police had to determine if she'd gone on vacation without telling anyone, or if she was the victim of foul play.
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The body of a college co-ed was found on a farm covered with her own denim as well as the jeans of the killer.
When a little girl got sick and died, investigators were stumped. Was it an accident, an unexplained illness or murder?
In 2007, Shamaia Smith disappeared from the strip club she worked at in East Hartford, CT. Police look at various customers of the strip club, but focus on local businessman Kenneth Otto.
In 1991, Dorothy Donovan was murdered in her Dover, Delaware home and police are skeptical when her son Charles Holden stated that she was murdered by a hitchhiker he had picked up.
A young, attractive hairdresser was sexually assaulted and murdered in her own beauty salon. The evidence at the crime scene didn't match any of the suspects and the case went cold for ten years.
In the 1990s, the media dubbed Richard Rogers the "Last Call Killer" because he targeted men in gay bars.
A young woman is found dead in her apartment. With little evidence at the scene, the case turns cold.
A man's wife took her own life and his college sweetheart killed herself the same way. Was it coincidence?
When a man's story of a killing contradicted physical evidence, investigators turned to forensic science.
The crime scene was especially violent: A couple had been shot to death. Was their teenage daughter complicit?
A young woman attends evening church services... then disappears. When her abandoned car is found, the tank is empty and a gas can she kept in her trunk for emergencies is missing.
In 1996, Derrick Duehren returned to find his Oregon home burned to the ground. His wife's charred remains were later found in the rubble.
Two suspects are linked to a murder by bloodstained boots and a gun, but the owner of the items says he has never met the victim.
A fireman died from what appeared to be heart disease, but his family was skeptical of the cause of death.
In 2006, Nevada politician Kathy Augustine died mysteriously during a hard-fought re-election campaign and the medical examiner could neither isolate the cause of death.
The body of a young girl was discovered on isolated farmland near Delano, California. She had no ID, but police found mailbox keys in the pocket of her jeans.
The victim has been stabbed more than thirty times, and the crime scene is awash with her blood. Near her head, police discover a distinctive button with strands of thread still attached.
An 82-year-old woman was found dead. Clues on the victim's body would tell police what happened that night.
In 2002, funeral director Lonnie Turner, Sr. was found shot to death. His son Lonnie Jr. became the prime suspect, particularly after it was discovered that the murder was committed with his gun. However, he had an alibi for the time of the murder.
In one of the most brazen crimes of the 20th century, the chairman of the Coors Brewing Company was kidnapped.
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