Prue and Phoebe break a code of conduct to cure Piper when she is hospitalized with a deadly disease, but the illness is spread to other patients.
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Pandora's Box falls into the hands of a shape-shifting demon (Michelle Hurd) who intends to open it and release all of its sorrows into the world, sending the sisters on a search for Hope (Brooke Nevin).
Zankou uses his underlings to lure the sisters out of their house, so he can search for the Nexus and release the Shadow, the ultimate power.
Piper is attacked by demons and winds up in a coma, and as she hovers between life and death, her spirit meets Cole (Julian McMahon), who says he is trying to help restore Phoebe's faith in love.
When Inspector Morris believes his friend is possessed, the Charmed Ones investigate and find that a victim of a fire in 1899 has taken control of Mike.
When Paige tries to hire a new professor for the Magic School, one of the candidates, Drake (Billy Zane), turns out to be an ex-demon who made a deal with a sorcerer to become human.
Leo learns that the Charmed Ones' conflict-free world comes with a high price, so he teams with Zankou (Oded Fehr) to stop the Avatars and reverse the change.
While the Avatars prepare to transform the world into a utopia, Brody is kidnapped by Zankou and forced to place a paranoia spell on the Charmed Ones.
When Piper tries to switch powers with Phoebe so that she can see Phoebe's vision for herself, the demon Zankou (Oded Fehr) attacks the women and causes their abilities to be transferred to innocents.
Grams puts a spell on the brothers to end their rivalry, but the spell turns the Charmed Ones into bickering teens Leo consults a demonic seer (Charisma Carpenter) to find out who is behind the attack on Wyatt.
When a bored student at the Magic School accidentally conjures up Lady Godiva and Lord Dyson, the Charmed Ones must keep Dyson from killing Lady Godiva before she can go back in time and complete her famous ride.
After Leo and Piper inadvertently receive the powers of Hindu gods, Phoebe and Paige must keep them from consummating their love in order to save the universe.
Phoebe and Paige attempt to rescue Chris and Leo but find themselves battling their evil counterparts.
Gideon unintentionally creates a portal that sends Chris and Leo to an alternate world where evil rules.
Gideon (Gildart Jackson) conspires with two demons to make Piper, Phoebe and Paige part of "Witch Wars," a new demonic reality television show where demon contestants compete in a series of contests to hunt down the Charmed ones.
With Piper away at magic school and Phoebe without her active powers, overworked Paige conjures Mr. Right (Gabriel Olds) for stress relief but, unknowingly, releases his evil twin, Mr. Wrong.
When the Charmed Ones are caught on tape using their powers, the Cleaners cover up the situation by framing Darryl as a murderer and sending him to death row.
Paige and Phoebe conjure up Mr. Right as a birthday present for Piper Chris convinces the sisters to bind Wyatt's powers, then demonic cult members kidnap the youngster.
Paige tries on a pair of Grams' go-go boots and goes back in time Leo and Chris try to stave off an amorphous creature surrounding the manor.
A mysterious woman from the future (Marisol Nichols) arrives to take Chris' powers the Power of Three is endangered when Paige moves in with Richard and Phoebe joins Jason in Hong Kong.
After vanquishing a Manticore demon, the sisters become foster parents to its orphaned baby Phoebe surprises her boyfriend by blurting out her true feelings.
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