After losing two elderly patients, a young nurse (Megan Porter Follows) is found holding a syringe containing poison and charged with murder.
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Murder ends a tycoon's (James Coco) plan to have Jessica design a house of horrors for one of his theme parks.
Jessica helps clear her neighbor (Van Johnson), an eccentric suspected of murdering with one of his inventions.
Jessica sets out to prove her secretary isn't a murder suspect.
Jessica delves into two investigations when both her wealthy Southern cousin and his daughter die mysteriously.
Jessica is suspected of a producer's murder after people hear her threatening to stop the victim from filming her new novel.
Jessica travels to San Francisco for a family wedding and discovers that the groom (Jeff Conaway) faces a murder charge.
A financier (Howard Duff), reportedly swept overboard during a hurricane, turns up in Jessica's yard disguised as a handyman.
Jessica investigates the death of a slave who was accused of murdering a plantation owner in the 1860s.
While at a writer's conference, Jessica Fletcher (Angela Lansbury) tries to solve the murder of a man who wrote a nonfiction book about the KGB.
Jessica seeks a woman who witnessed the murder of a government whistleblower.
After a San Francisco radio station changes its music format from classical to rock, the promoter who engineered the switch dies and Jessica searches for the killer.
While Jessica is in Atlanta to address mystery writers, a lethal virus is stolen from the Biological Research Institute.
When a young man dies in a motorcycle crash, and a local attorney is murdered, Jessica looks for links between the two seemingly unrelated deaths.
Details in a manuscript convince a young editor (Tracy Middendorf) that the author (Richard Beymer) kidnapped her 11 years earlier, but when the author is found dead, the editor becomes the primary suspect.
Seth Hazlitt's benefit concert to save the woods near Cabot Cove is endangered when the lead singer is permanently silenced.
Jessica works hard to get her friend's (Tony Plana) Latino band a recording contract, until a murder rocks her plans.
In Japan, Jessica gets involved in the murder of a motorcycle racer, the son of an international CEO (Pat Morita).
After being subpoenaed to testify at the jury probe of a brokerage house, Jessica is charged with contempt for speaking to a witness who is killed.
When Jessica arrives at an ice cream company to get a check for charity, the funds have melted away and the company's co-founder is iced.
Detective Charlie Garrett's (Wayne Rogers) high bid on a mediocre painting puzzles Jessica then, its second-rate artist is found dead.
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