Following last season's cliffhanger ending, Walt (Bryan Cranston) and Jesse (Aaron Paul) anxiously wait to see what their drug lord boss, Gus (Giancarlo Esposito), will do next. Meanwhile, Skyler (Anna Gunn) desperately searches for clues to Walt's activities, while Hank (Dean Norris) continues his slow, painful rehab.
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As Hank (Dean Norris) produces evidence that Gus (Giancarlo Esposito) is Albuquerque's meth kingpin, Walt (Bryan Cranston) worries that both he and Jesse (Aaron Paul) are going to be killed to protect their boss. Meanwhile, after refusing the Mexican cartel's demand to stop his drug trade, Gus returns to his roots as he fights back.
Upset at being ordered to return the car he bought for their son, Walt (Bryan Cranston) strikes back by placing Skyler (Anna Gunn) in a difficult spot with their new money laundering operation. And as Walt looks to protect himself by getting rid of Gus (Giancarlo Esposito), Jesse (Aaron Paul) agrees to be the hit man.
When Skyler suspects that Walt (Bryan Cranston) isn't telling her the truth, Skyler (Anna Gunn) adopts a cold and businesslike approach toward him. Meanwhile, as Gus (Giancarlo Esposito) draws him closer, Jesse (Aaron Paul) proves his worth to Mike and Gus' enterprise.
While Walt (Bryan Cranston) worries that his partner is about to be killed, Jesse (Aaron Paul) is with Mike on a perilous run. Meanwhile, as Walt and Skyler (Anna Gunn) close the car wash deal, Hank (Dean Norris) decides to close his investigation.
As Skyler (Anna Gunn) concocts an elaborate story to explain their finances, Walt (Bryan Cranston) worries when he discovers that Hank (Dean Norris) has begun a new investigation. Meanwhile, Jesse's (Aaron Paul) lack of interest in doing anything but partying catches Gus' attention.
While Walt (Bryan Cranston) worries about Gus's interference and Jesse's (Aaron Paul) increasingly fragile state of mind, Skyler (Anna Gunn) steps up the pressure to get what she wants. Hank's (Dean Norris) moodiness drives Marie (Betsy Brandt) to lapse into some bad habits, which unwittingly uncovers a link that threatens to expose Walt and Jesse.
Walt (Bryan Cranston) prepares his defense against Gus as Jesse copes by reviving his friendship with Badger and Skinny Pete. Meanwhile, as Skyler (Anna Gunn) hatches a scheme of her own, her sister Marie (Betsy Brandt) struggles to deal with Hank's (Dean Norris) deep depression.
Following the disappearance of Brianna Norton, Jess's disturbing dream about the twenty-eight-year-old woman leads the FBI to Philadelphia.
With Jess working on an undercover sting with Burgess, Brooke worries that an old friend at the Bureau may be behind a controversial author's kidnapping.
The disappearance of a prominent biochemist who holds the key to a valuable weight loss drug brings Brooke face-to-face with her estranged father.
Jess goes undercover at a prestigious military academy to investigate the disappearance of a new cadet.
A brilliant serial killer returns to seek revenge against Brooke for being sent to prison.
Jess and Nicole investigate the disappearance of a woman who they suspect may be involved in an elaborate -- and deadly, embezzlement scheme.
A teenaged girl's disappearance moves Jess from the Academy to partnering with Special Agent Nicole Scott.
A facts driven no nonsense FBI agent assigned to missing-persons cases is reluctantly paired with a teen girl psychic whose visions show clues to the location of the missing.
The search for a bone marrow donor sends Brooke and Jess looking for a man who has disappeared from the witness protection program.
The death of a powerful Cleveland organized crime boss draws Jess into a potentially deadly search for the mobster's missing wife.
Jess is sent to North Carolina to help find a woman who disappeared from an aircraft seemingly in-flight.
A depressed schizophrenic's disappearance puts an innocent boy in danger as it threatens to expose a psychiatrist's role in a patient's death.
Word of a wealthy couple's disappearance sends Brooke and Jess deep into a remote wilderness area to find them and their Eco-terrorist kidnappers.
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