In 2004, Mary Ann Clibbery was found brutally murdered in her Illinois business and investigators had to determine if this was a robbery gone wrong or a calculated murder.
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After a Philadelphia convention, 180 legionnaires contract pneumonia-like symptoms and 29 of them die.
In 1996, 17-month-old Josh Hinson died in a fire which a federal agency ruled was intentionally set by Josh's mother Terri Strickland. Using the then-emerging resources of the Internet, Terri Strickland undertook her own investigation.
When a surgeon is found dead in his home, police assume it was suicide. The investigation reveals otherwise.
In 1991, San Francisco pornographer Artie Mitchell was murdered in his home. His brother and business partner Jim is found near the scene carrying a rifle and later confesses to shooting Artie. The question is whether the shooting was premeditated.
An investigation of a pediatrician, prompted by the death of one of her patients, leads to a Texas hospital where the pediatric mortality rate is higher than at any hospital in the country.
In 1996, when a fundamentalist group starts attacking and robbing banks in Spokane, Washington, authorities know immediately that they are dealing with experienced criminals.
In 1993, Marie Robards suffered the loss of her father due to a heart attack - but it was more sinister.
When a policeman's house goes up in flames, experts suspect arson. The officer whose home was torched arrests a low-level drug dealer, who confesses. But then the suspect vanishes.
In 1981, six-year-old Cassie Hansen disappeared from her St. Paul, Minnesota church during an evening service.
A fan of murder mysteries and forensic science shows uses what she learned from TV to determine who was responsible for the accident which permanently injured her 4-year-old daughter.
In 1981, New York correctional officer Donna Payant disappeared and was later found in a landfill. The medical examiner not only identified the cause of death but also found an important clue.
In 1980, Michigan resident Shannon Mohr died in what was reported to be a horseback riding accident by her new husband David Davis. After her death, Shannon's family reported to police their suspicions that Davis seemed far from grief-stricken.
Early one morning in a deserted area outside of Phoenix, a motorcyclist discovered the body of a young woman.
In 1994, Rhoda Nathan was found murdered in a Cincinnati hotel room. When hotel employee Elwood Jones visited the emergency room for an infected hand, which he said was cut on a dumpster, the doctor recognized the injury as something else.
Lisa Manderach and her daughter Devon left their Pennsylvania home to go shopping but didn't return home.
Sometime during a neighborhood Christmas party, five-year-old Melissa Brannen disappeared. Investigators turned to forensic science to help them see what the witnesses missed.
A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.
When a decomposed body is found stuffed in a barrel, it's easy to presume murder. One of the few clues was an address book found along with the body.
An 11-year-old Boy Scout comes down with a fever and diarrhea after eating an undercooked burger. When his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.
While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.
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