When Genell Plude is found dead in her bathroom, the scene points to suicide. But a coroner's inquest and a unique application of forensic science gave investigators a different explanation for her death.
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Who was the sexual offender who murdered two boys in Nebraska? The key to stopping him would be the unique composition of the "junk rope" he used to tie his victims.
On a cold December night in 1993, Rose Larner stopped in a convenience store on her way to her boyfriend's house. She was never seen or heard from again. A tiny clue found years later revealed a tragic tale of drugs, romance and revenge.
A surgeon is stabbed to death, and the most likely suspect is seen in a restaurant at the time of the murder.
An assistant manager of a Florida steakhouse is stabbed to death. It appears to be a robbery gone wrong.
A woman was found dead on a golf course. The grass on the course was so distinctive, it had evidentiary value.
In 1993, Marie Robards suffered the loss of her father due to a heart attack - but it was more sinister.
In 2004, nursing student Tamika Huston went missing from her Spartanburg, South Carolina home. A tip led detectives to her car, where they found an unknown house key that could help solve the case.
The only clue recovered from a shooting is a twelve-guage shotgun. Scientists use unique methods to lift the serial number from the weapon to trace it to its owner
A woman's death in Pennsylvania triggers a homicide investigation into another woman's death in North Carolina.
Timothy Wilson Spencer was identified as the man who raped and strangled five young women in Virginia. With the use of DNA profiling, an innocent man is freed and the real killer is convicted.
While investigating the murder of 9-year-old Jessica Knott, police use a garbage bag to connect a suspect.
When a pipe bomb rips through a rural home, killing a young man and seriously injuring his mother, detectives hope that the remnants of a mailing label will lead them to a killer.
On May 12, 1994, Crystal Perry was viciously murdered in her home in Bridgton, Maine. Michael Hutchinson, 32, was found guilty of murder in the 1994 slaying at Perry's home.
In 1971, John List left a note with the bodies of his family members in his mansion before he disappeared.
A car carrying three men pulls up alongside another on an Alaskan highway and fires shots, leaving a passenger dead. One of the passengers in the killer's car agrees to testify against his friends. The resulting trials don't end the carnage.
A lifelong resident of the tiny town of Lefroy, Tasmania was murdered outside his own home. Robbery appeared to be the motive, but with no suspects, the investigation came to a halt.
Police exhume the body of Karla Brown, murdered in her home in 1978, to study bite wounds, which eventually lead to the killer.
Police are able to create a composite sketch of a man burnt beyond recognition. But tracking the killer is more challenging.
In 1993, young mother Tammy Tatum was sexually assaulted and murdered in her Longmont, Colorado apartment.
On May 12, 1994, Crystal Perry was viciously murdered in her home in Bridgton, Maine. Michael Hutchinson, 32, was found guilty of murder in the 1994 slaying at Perry's home.
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