In a desert infested with strange new vampires, Flesh and Axel chase a crazed Max who has Jennifer and Owen held hostage. When night falls, their chances of survival turn for the worse.
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On a distant island, Vanessa and Scarlett battle the Third Elder which leads Vanessa to make a choice about her path forward, one that Scarlett does not agree with.
Sam moves closer to his destiny while Mohamad tries to free himself from imprisonment. Axel escorts San Francisco survivors to Denver. Ivory and Scab take control of the Daywalker horde.
Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces. In Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.
Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.
Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong. There, she learns to control her dark side and fights the B'ah, the second vampire Elder.
To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.
Vanessa is once again resurrected and must confront her family's legacy. Axel, Scarlett, and the others fend off Blak Tek's forces who hope to add Scarlett to their list of lab rats.
Vanessa faces off with Dmitri. Axel fights against becoming a full-fledged vampire. Sam tracks Mohamad, Flesh, and Lucky. Scab attempts to enlist a fierce group of vampires to join Dmitri.
Vanessa faces off with Dmitri. Axel fights against becoming a full-fledged vampire. Sam tracks Mohamad, Flesh, and Lucky. Scab attempts to enlist a fierce group of vampires to join Dmitri.
Vanessa's past rushes back to confront her in an unexpected way. A secret that Doc has been protecting is revealed. In a bid to bolster his power, Dmitri sends Scab on an impossible mission.
Vanessa faces off against Sam in a bloody showdown. Dmitri hears news that sends him on a warpath after Vanessa. Flesh, Mohamad, and Lucky take desperate steps to save their lives.
Vanessa encounters a group of vampires whose gruesome methods bring savagery to a new level. The Juvenile Delinquents continue their game of cat and mouse with Sam that has deadly consequences.
Vanessa makes a horrific decision to save her daughter. Axel and a former ally struggle to survive in the wild.. A group of juvenile delinquents come face to face with a sadistic vampire.
Vanessa fights to get her daughter out of the citadel. Dmitri and Antanasia hatch a plot to stop Vanessa. Mohamad risks his life to save Vanessa and Dylan.
Vanessa and Mohamad search for Dylan as Dmitri's citadel crumbles around them. Flesh acquires an unexpected ally in one of the Resistance Fighters. Taka clashes with the Vampire Elite.
Now in Dmitri and Rebecca's clutches, Vanessa learns secrets from her past and finds herself at a crossroads - is she a vampire or a human?
Vanessa and Susan are pursued through the sewers by mutated feral vampires and arrive back at the safety of the hospital only to find the aftermath of a hostile takeover.
Vanessa, now in the clutches of Julius and his vampire brood, is forced to demonstrate her powers against someone from her past.
Vanessa and Mohamad head into the vampire-controlled streets in search of Dylan, the daughter that Vanessa orphaned when she 'died'.
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