Three generations of Van Helsings come together before a final showdown with Elder Sam and the Oracle. When the portal to the Dark Realm is opened an ancient evil is released: The Dark One.
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Vanessa has a final showdown with the Second Elder in San Francisco. In Denver, Flesh, Doc, Julius and Jolene learn that even in a Safe-Zone, life isn't easy.
In San Francisco, Vanessa, Scarlett and Axel find and battle against the Second Elder's forces. In Denver, Flesh, Doc, Julius and Jolene rejoin American civilization as best they can.
Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.
Vanessa relives the memories of her ancestor, Lily Van Helsing, in Colonial Hong Kong. There, she learns to control her dark side and fights the B'ah, the second vampire Elder.
To find its totem, the First Elder brings Vanessa, Scarlett and Axel to an abandoned insane asylum protected by powerful vampires, where they discover the legacy of a long dead Van Helsing relative.
Vanessa is once again resurrected and must confront her family's legacy. Axel, Scarlett, and the others fend off Blak Tek's forces who hope to add Scarlett to their list of lab rats.
At a mountain stronghold, secrets of the Van Helsing family are unearthed and the true face of evil is exposed. A climactic battle between humans and vampires leaves humanity's fate in question.
While the rest of the group fight for survival, Axel and Scarlett defend a mountain stronghold against a relentless foe. Doc makes a medical discovery that could change everything.
Vanessa faces off against Sam in a bloody showdown. Dmitri hears news that sends him on a warpath after Vanessa. Flesh, Mohamad, and Lucky take desperate steps to save their lives.
Vanessa encounters a group of vampires whose gruesome methods bring savagery to a new level. The Juvenile Delinquents continue their game of cat and mouse with Sam that has deadly consequences.
Vanessa makes a horrific decision to save her daughter. Axel and a former ally struggle to survive in the wild.. A group of juvenile delinquents come face to face with a sadistic vampire.
Vanessa fights to get her daughter out of the citadel. Dmitri and Antanasia hatch a plot to stop Vanessa. Mohamad risks his life to save Vanessa and Dylan.
Vanessa and Mohamad search for Dylan as Dmitri's citadel crumbles around them. Flesh acquires an unexpected ally in one of the Resistance Fighters. Taka clashes with the Vampire Elite.
Now in Dmitri and Rebecca's clutches, Vanessa learns secrets from her past and finds herself at a crossroads - is she a vampire or a human?
While on the road to a vampire-controlled camp, Vanessa and Mohamad find themselves in a dangerous game of cat-and-mouse against Sam.
Vanessa and the group take shelter in Susan's family farm, finding both glimmers of hope and reasons for grief.
When the hospital's power source is damaged, Vanessa and the survivors only have three hours of reserve power for the UV lights - the only thing keeping the vampires at bay.
In the days leading up to 'The Rising', Vanessa is attacked and left for dead by an intruder.
Three years after 'The Rising' began, Vanessa - a mysterious dead woman - is resurrected in a world now ruled by vampires.
In the series finale, Vanessa assaults the Dark One in the Oval Office with daughters Violet and Jack, while Axel and Ivory protect a new government.
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